Product Description:

99.5% High Purity Tadalafil , Raw Cialis Steroids Powder For Pharmaceutical

Quick Detail:

Tadalafil, known under the brand name Cialis for the treatment of erectile dysfunction and Adcirca for pulmonary arterial hypertension, is a PDE5 inhibitor. Its main competitors are sildenafil citrate (Viagra) and vardenafil (Levitra).
Cialis became nicknamed "the weekend pill" because its effects last 36 hours. Viagra and Levitra are effective for up to 8 hours.

Description:

Tadalafil
Alias: Tadalafei;Cialis
CAS No: 171596-29-5
MF: C22H19N3O4
MW: 389.41



Purity: 99.5%
Appearance: white powder, odorless, tasteless, insoluble in water and alcohol.

How does an erection occur? What does Cialis do?
Penile erection occurs when the penis fills with blood. This happens because the blood vessels that bring blood flow to the penis dilate, thus increasing the blood supply. Simultaneously, the blood vessels that remove blood from the penis contract, so that blood accumulates (resulting in an erection).
When a man is sexually stimulated nitric oxide is released into the penis. Nitric oxide makes guanylate cyclase (an enzyme) produce cGMP (cyclic guanosine monophosphate). cGMP controls the dilation and contraction of the blood vessels that carry blood to and from the penis - when those supplying the penis with blood are dilated, and the others that remove blood from the penis are contracted, an erection occurs.
Another enzyme, phosphodiesterase-5 destroys cGMP. When this occurs the blood vessels return to their normal size and the erection ends. Tadalafil stops phosphodiesterase-5 from destroying cGMP, i.e. it prolongs the duration of cGMP, which results in a prolonged and better erection.

Applications:
Cialis (tadalifil) is the second-generation Viagra, more or less. While the little blue pill may work to give you an erection for 6-8 hours, Cialis is good for 36-48 hours. This obviously makes it much more practical. Why are we talking about this? I doubt anyone using endogenous testosterone would need to consider the use of such a compound, but this drug can still have some uses during post cycle therapy. A lot of men find that once they go off steroids and begin post cycle therapy (PCT), they suffer reduced libido as well as erectile dysfunction. Cialis may be useful for helping this, at least during PCT.

The efficacy and safety of tadalafil for the treatment of erectile dysfunction was assessed in a 6-month study. Men with mild, moderate or severe ED were given tadalafil (20 mg) as needed or placebo ("any minute now, baby, no, really"). Tadalafil significantly improved erectile function compared with placebo (which only succeeded in embarrassing the men who took it and tried to get laid). At the end of the study, sexual intercourse attempts success rate for those using Cialis was 73.5% (this only refers to the ability to achieve erection and have intercourse, not the actual success rate of those attempting to get laid on a given night)

Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.

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